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The combinatory effects, including additive, synergistic, antagonistic, and suppression, (C) are quantified by isobologram analysis. Depending on the combination and timing, such as acute versus preventive strategies, even antagonistic and suppression effects may have long-term beneficial outcomes like collateral sensitiv- ity and cross-sensitization, potentially leading to new therapeutic strategies (D,E).
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Smart Medications > Deep Dive > Systems Medicine